My review of Resident Evil 5 is up at SciFiWire.com. It's been a while since I played any of the Resident Evil titles, and the transition from the old survival-style games to the new run-and-gun games (ok, more like "run and then gun" games) was a bit jarring.
The current Resident Evil game is also obviously influenced by the movie series; there are a lot of cinematic, super-cool interactive cut scenes that could have been ripped from any of the films (dodging a possessed, chain-wielding motorcycle gang for example) but it's a hybridization that works.
The run-stop-shoot mechanic in this game is going to infuriate FPS veterans, but honestly, those folks should be playing Left4Dead instead; it's horde mechanics and four-player co-op play is more in line with what they want anyway. For those who like to be a bit more methodical (and occasionally panicked) in their zombie playing should enjoy Resident Evil 5.
On a related note, there's a new Resident Evil 4 out for the Wii that's supposed to take advantage of its interface; what I've read about it so far sounds cool, and I'm thinking of renting a copy just to see how it plays compared to RE5 on the 360.