A D&D 4th-edition powered version of Metamorphosis Alpha -- the first-ever SF role-playing game -- is being released by Signal Fire Studio. The original game took place aboard the generational starship Warden in the centuries after the vessel was badly damaged, killing much of its crew and mutating the survivors. It inspired the classic Dungeons & Dragons module Expedition to Barrier Peaks and inspired the Gamma World RPG.
The new game will stick to the same premise of the original, with mutants, intelligent plants, and other heroes delving into the celestial remains of the Warden, all the while never realizing its a starship. Check out the press release for more details.
I think this could work; one of the problems my group ran into with D&D 4th Edition didn't feel enough like our D&D. Transport the rules to another setting or genre -- say science fiction or superheroes -- and I think a lot of our emotional baggage relating to the game would evaporate. I'm also curious to see how the 4E ruleset handles being transported to another genre; my gut says it will do pretty well, especially in as morphic a setting as Metamorphosis Alpha.